Barbiturate Protection From Cerebral Infarction in Primates-Reference-Cited by-同舟云学术

Barbiturate Protection From Cerebral Infarction in Primates

Published:1975-01 Issue:1 Volume:6 Page:28-33
ISSN:0039-2499
Container-title:Stroke
language:en
Short-container-title:Stroke

Author:

HOFF JULIAN T.¹²,SMITH ALLAN L.³,HANKINSON f HAL L.¹,NIELSEN SURL L.⁴

Affiliation:

1. Departments of Neurological Surgery, San Francisco General Hospital, University of California School of Medicine, San Francisco, California 94143

2. Recipient of Teacher-Investigator Award NS 11051. Recipient of Career Development Award GM 70770.

3. Departments of Anesthesiology, San Francisco General Hospital, University of California School of Medicine, San Francisco, California 94143

4. Departments of Pathology, San Francisco General Hospital, University of California School of Medicine, San Francisco, California 94143

Abstract

Baboons were anesthetized with halothane or pentobarbital prior to middle cerebral artery (MCA) occlusion to test the protective effect of barbiturates against stroke in primates. Significantly less infarction was found in animals that received 90 mg per kilogram pentobarbital or more than occurred in control animals. Because of cardiovascular and ventilatory complications at high doses of barbiturate, however, therapeutic trials to suppress stroke in the human must await further identification of an effective regimen which includes a safe barbiturate dose.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Advanced and Specialised Nursing,Cardiology and Cardiovascular Medicine,Clinical Neurology

Link

https://www.ahajournals.org/doi/pdf/10.1161/01.STR.6.1.28

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5. Protective Action of some Anaesthetics Against Anoxia

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