1. From the Department of Bioengineering, Imperial College London, London, United Kingdom (R.M.P., S.M.B., V.V.M., R.K.); NHLI, Imperial College London and NIHR Cardiovascular Biomedical Research Unit, Royal Brompton and Harefield NHS Foundation Trust, London, United Kingdom (R.d.S.); and MRC-Clinical Sciences Centre, Imperial College London, London, United Kingdom (E.P.).