1. From the Centre for Clinical Pharmacology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom (Q. Xiao, S.Y.); Cardiovascular Division, King's College London British Heart Foundation Centre, London, United Kingdom (G.W., X.Y., Z.L., A.M., L.Z., M.M., Q. Xu).