Mesenchymal Stromal Cells Facilitate Tip Cell Fusion Downstream of BMP-Mediated Venous Angiogenesis

Mesenchymal Stromal Cells Facilitate Tip Cell Fusion Downstream of BMP-Mediated Venous Angiogenesis—Brief Report

Published:2023-07 Issue:7 Volume:43 Page:
ISSN:1079-5642
Container-title:Arteriosclerosis, Thrombosis, and Vascular Biology
language:en
Short-container-title:ATVB

Author:

Eisa-Beygi Shahram¹,Hu Meng-Ming¹^ORCID,Kumar Suresh N.²^ORCID,Jeffery Brooke E.¹^ORCID,Collery Ross F.¹³^ORCID,Vo Nghia (Jack)⁴⁵^ORCID,Lamichanne Bhawika S.⁶,Yost H. Joseph⁶,Veldman Matthew B.¹^ORCID,Link Brian A.¹^ORCID

Affiliation:

1. Department of Cell Biology, Neurobiology and Anatomy (S.E.-B., M.-M.H., B.E.J., R.F.C., M.B.V., B.A.L.), Medical College of Wisconsin, Milwaukee.

2. Department of Pathology (S.N.K.), Medical College of Wisconsin, Milwaukee.

3. Department of Ophthalmology and Visual Sciences (R.F.C.), Medical College of Wisconsin, Milwaukee.

4. Department of Radiology (N.V.), Medical College of Wisconsin, Milwaukee.

5. Department of Radiology, Pediatric Imaging and Interventional Radiology, Children’s Hospital of Wisconsin, Milwaukee (N.V.).

6. Molecular Medicine Program, Eccles Institute of Human Genetics, University of Utah, Salt Lake City (B.S.L., H.J.Y.).

Abstract

Background: The goal of this study was to identify and characterize cell-cell interactions that facilitate endothelial tip cell fusion downstream of BMP (bone morphogenic protein)-mediated venous plexus formation. Methods: High resolution and time-lapse imaging of transgenic reporter lines and loss-of-function studies were carried out to study the involvement of mesenchymal stromal cells during venous angiogenesis. Results: BMP-responsive stromal cells facilitate timely and precise fusion of venous tip cells during developmental angiogenesis. Conclusions: Stromal cells are required for anastomosis of venous tip cells in the embryonic caudal hematopoietic tissue.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Cardiology and Cardiovascular Medicine

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