2016 Jeffrey M. Hoeg Award Lecture-Reference-Cited by-同舟云学术

2016 Jeffrey M. Hoeg Award Lecture

Published:2018-08 Issue:8 Volume:38 Page:1678-1688
ISSN:1079-5642
Container-title:Arteriosclerosis, Thrombosis, and Vascular Biology
language:en
Short-container-title:ATVB

Author:

Rouwet Ellen¹,Lutgens Esther²³

Affiliation:

1. From the Department of Surgery and Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands (E.R.)

2. Department of Medical Biochemistry, Experimental Vascular Biology Laboratory, Academic Medical Center, Amsterdam, The Netherlands (E.L.)

3. Institute for Cardiovascular Prevention (IPEK), Ludwig Maximilian’s University (LMU), Munich, Germany (E.L.).

Abstract

Innate and adaptive immune effector mechanisms, in conjunction with hyperlipidemia, are important drivers of atherosclerosis. The interaction between the different immune cells and the secretion of cytokines and chemokines determine the progression of atherosclerosis. The activation or dampening of the immune response is tightly controlled by immune checkpoints. Costimulatory and coinhibitory immune checkpoints represent potential targets for immune modulatory therapies for atherosclerosis. This review will discuss the current knowledge on immune checkpoints in atherosclerosis and the clinical potential of immune checkpoint targeted therapy for atherosclerosis.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Cardiology and Cardiovascular Medicine

Link

https://www.ahajournals.org/doi/pdf/10.1161/ATVBAHA.118.307742

Reference124 articles.

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2. Monocyte-Macrophages and T Cells in Atherosclerosis

3. Artery Tertiary Lymphoid Organs Contribute to Innate and Adaptive Immune Responses in Advanced Mouse Atherosclerosis

4. Innate sensing of oxidation-specific epitopes in health and disease

5. Adaptive (T and B Cells) Immunity and Control by Dendritic Cells in Atherosclerosis

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