1. From the Department of Medicine, Section of Pulmonary, Critical Care and Sleep Medicine (M.H., I.D., Y.Z., P.M., P.J.L.), Section of Cardiovascular Disease (Y.H., K.S.R, F.G.), and Section of Endocrinology and Metabolism (M.J.J.), Yale University School of Medicine, New Haven, CT; and Department of Pathobiology, Lerner Research Institute and Respiratory Institute, Cleveland Clinic, OH (S.C.E.).