1. From the Department of Biochemistry (Y.K., T.M., X.-F.L., T.O., J.-r.K.-K., S.T., A.M.) and Department of Anatomy (T.N., S.S.), Showa University School of Medicine, Tokyo, Japan; Center for Biotechnology, Showa University, Tokyo, Japan (T.N.); Division of Endocrinology and Metabolism, Showa University Fujigaoka Hospital, Yokohama, Kanagawa, Japan (Y.K., M.T.); and Laboratory of Regulatory Biology, Graduate School of Science and Engineering, University of Toyama, Toyama, Japan (T.N.).