1. From the Department of Physiology (M.B., M.R.T., L.G., N.E.B., H.J.J., A.E.K.), the Human and Molecular Genetics Center (M.B., M.R.T., L.G., N.E.B., T.W., H.J.J., A.E.K.), and the Division of Biostatistics (T.W.), Medical College of Wisconsin, Milwaukee, and the Faculte de Pharmacie-Université Lyon 1 (A.B., M.V., J.S.), Lyon, France.