1. From the Department of Medicine (V.J., K.H., S.K.G.M., G.E., T.P.), University of Würzburg, Würzburg, Germany; Pharmaceutical and Medicinal Chemistry (P.K., E.B., R.W.H.), Saarland University, Saarland, Germany; Schering AG (K.-H.F., K.P., C.H.-H.), Berlin, Germany; and the Division of Cardiology (L.N.), University of Manchester, Manchester, United Kingdom.