1. From the Departments of Clinical Pharmacology and Therapeutics (H.M., K.A., T.O., K.T., Y.I) and Drug Development and Clinical Evaluation (T.O., M.K., J.H.), Environmental Health Sciences (H.S.), Tohoku University Graduate School of Pharmaceutical Science and Medicine, Comprehensive Research and Education Center for Planning of Drug Development and Clinical Evaluation, Tohoku University 21st Century COE Program, Sendai; and Ohasama Hospital (H.H.), Iwate, Japan.