1. From the ADAPT Centre, Beaumont Hospital and Department of Clinical Pharmacology (E.D., N.A., P.M.C., S.M.C., E.O., A.V.S.), Royal College of Surgeons in Ireland, Dublin, Ireland; Study Coordinating Centre (L.T., Y.L., J.A.S.), Laboratory of Hypertension, Hypertension and Cardiovascular Rehabilitation Unit, Department of Cardiovascular Diseases, University of Leuven, Belgium.