1. From the Department of Internal Medicine, Graduate School of Medicine, University of Tokyo (T.O., T.A., K.A., Y.C., N.S., M.F., H.K., Y.F., T.F.), Tokyo; The Institute for Adult Diseases, Asahi Life Foundation (T.O., H.S., M.A., H.O., Y.O., M.K.), Tokyo; Research Center for Advanced Science and Technology, University of Tokyo (N.N., H.A.), Tokyo; and Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine (I.K.), Chiba, Japan.