1. From the Department of Pharmacology and Toxicology (M.W.S., G.E.F., G.M.J.J., J.G.R.D.M.), Cardiovascular Research Institute Maastricht (CARIM), University of Maastricht; Department of Internal Medicine (P.W.d.L.), University Hospital Maastricht; Department of Pediatrics (C.E.B.), Research Institute Growth and Development (GROW), University of Maastricht, the Netherlands.