Paradoxic Action of Amyl Nitrite in Coronary Patients

Author:

CONTRO STEPHEN1,HARING OLGA M.1,GOLDSTEIN WALTER1

Affiliation:

1. From the Laboratory of Cardiology, Chicago Medical School, and the Mount Sinai Hospital of Chicago.

Abstract

Amyl nitrite inhalation in patients with sclerotic coronary vessels is followed by electrocardiographic changes typical of temporary coronary insufficiency. It is suggested that, in such cases, a slight increase of cardiac work (tachycardia) together with a decrease of blood supply (fall in blood pressure), leads to myocardial ischemia. Comparison between an exercise test and amyl nitrite inhalation in the same patients indicates similar results. Amyl nitrite inhalation may be used as a simple functional test in borderline or questionable cases of coronary heart disease.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine

Reference19 articles.

1. The Bradshaw Lecture on some New Vaso-Dilators: Delivered before the Royal College of Physicians of London

2. ON THE USE OF NITRITE OF AMYL IN ANGINA PECTORIS.

3. 5SOLLMAN T. A.: Manual of Pharmacology and its Application to Therapeutics and Toxicology ed. 4. Philadelphia Saunders 1932.

4. 6Francois-Frank C. A.: Effect vasodilatateur du nitrite d'amyle sur les vaisseaux de l'corce crebrale et sur les vaisseaux du myocarde. Compt. rend. Soc. biol. 55: 1448 1903.

5. Uber die XWirkung der Nitrite auf die Durchblutung des Herzens (Versuche am Herzen in situ). Deutsches Arch. klin;SCHLOSS K.;Med.,1913

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