Affiliation:
1. Escola Paulista de Medicina, Universidade de São Paulo, Brazil.
Abstract
It is well established that genetic and environmental factors are involved in the etiology of essential hypertension. The presence of genes predisposing to essential hypertension in the human leukocyte antigen (HLA) complex is controversial because studies of an association between HLA antigens and essential hypertension have failed to yield consistent results. Our aim in the present study was to further investigate this issue through the method of linkage analysis. Analysis of 96 hypertensive siblings distributed in 31 families indicated a significant distortion (p = 0.0009) of the normal segregation pattern of inheritance of HLA haplotypes. Thus, our data indicate that at least one of the genes responsible for genetic predisposition to essential hypertension is located very near or within the HLA complex.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Reference37 articles.
1. Editorial
2. Genetic Control of Blood Pressure by More than One Pair of Alleles
3. Morton NE Gulbrandsen CL Rao DC Rhoads GG Kagan A: Determinants of blood pressure in Japanese-American families. Hum Genet 180;53:261-266
4. Rapp JP: Genetics of experimental and human hypertension in Genest J Kuchel O Hamet P (eds): Hypertension. New York McGraw-Hill Book Co 1983 pp 582-598
5. Kaplan NM: Primary (essential) hypertension pathogenesis in Kaplan NM (ed): Clinical Hypertension. Baltimore Williams & Wilkins Co 1986 pp 56-122
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