Affiliation:
1. Department of AMES-Bioengineering, University of California, San Diego, La Jolla 92093-0412.
Abstract
The etiology for the progressive organ injury in hypertension is largely speculative. Recent studies have shown that leukocytes play a key role in several cardiovascular diseases. As an initial step toward investigating the role of leukocytes in hypertension, we measured leukocyte counts and spontaneous activation of granulocytes of freshly drawn unseparated blood samples in spontaneously hypertensive rats and in their normotensive counterpart, Wistar-Kyoto rats. The animals were derived from one breeder in the United States and from two breeders in Europe. Total leukocyte counts in young, mature, and old hypertensive rats were 50-100% above the controls. The number of granulocytes in mature and old spontaneously hypertensive rats in more than 100% elevated compared with control rats. In young hypertensive rats the mean granulocyte count was only slightly elevated. The number of spontaneously activated granulocytes, as detected by the nitroblue tetrazolium reduction, increases with age in both species; in mature spontaneously hypertensive rats, it is more than 300% above the values in the controls. Furthermore, in mature hypertensive rats the number of monocytes, activated monocytes, and the lymphocyte count are also significantly elevated over the values in the normotensive controls. It is proposed that these elevated leukocyte counts may constitute an enhanced risk for organ injury in the spontaneously hypertensive rat.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Reference52 articles.
1. Periarteritis nodosa in spontaneously hypertensive rats;Suzuki T;Acta Patholjpn,1980
2. Weksler BC McMurty JP lams SG: Histopathologic changes in aging male vs female spontaneously hypertensive rats. / Gerontol 1981;36:524-529
3. Hypertensive arterial disease and atherogenesis
4. Protection of ischemic myocardium by pharmacological manipulation of leukocyte function;Romson JL;Cardiovasc Rev Reports,1984
5. Role of leukocytes in the response to acute myocardial ischemia and reflow in dogs;Engler RL;Am J Physiol,1986
Cited by
176 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献