Arterial Stiffness and Cognition Among Adults: A Systematic Review and Meta‐Analysis of Observational and Longitudinal Studies

Author:

Alvarez‐Bueno Celia1,Cunha Pedro G.2,Martinez‐Vizcaino Vicente13,Pozuelo‐Carrascosa Diana P.1,Visier‐Alfonso Maria Eugenia1,Jimenez‐Lopez Estela145,Cavero‐Redondo Ivan1

Affiliation:

1. Universidad de Castilla‐La Mancha Health and Social Research Center Cuenca Spain

2. Internal Medicine Department Center for the Research and Treatment of Arterial Hypertension and Cardiovascular Risk Guimarães Portugal

3. Facultad de Ciencias de la Salud Universidad Autónoma de Chile Talca Chile

4. Department of Psychiatry Hospital Virgen de La Luz Cuenca Spain

5. CIBERSAM (Biomedical Research Networking Centre in Mental Health) Barcelona Spain

Abstract

Background To estimate the strength of the cross‐sectional and longitudinal association between arterial stiffness, measured by pulse‐wave velocity, and cognitive function, distinguishing between global cognition, executive functions, and memory and to examine the influence of demographic, clinical, and assessment characteristics on this relationship. Methods and Results Systematic review of MEDLINE (via PubMed), Scopus, and WOS databases from their inception to March 2019, to identify cross‐sectional and longitudinal studies on the association between pulse‐wave velocity and cognitive domains (ie, global cognition, executive functions, and memory) among adult population. A total of 29 cross‐sectional and 9 longitudinal studies support the negative relationship between arterial stiffness and cognitive function, including global cognition, executive function, and memory. Demographic, clinical, and assessment characteristics did not substantially modify the strength of this association. Conclusions Evidence reveals a negative association between arterial stiffness, measured using pulse‐wave velocity, and cognition, specifically executive function, memory, and global cognition. This association seems to be independent of demographic, clinical, and assessment characteristics. These results accumulate evidence supporting that pulse‐wave velocity assessment could be a useful tool to identify individuals at high risk of cognitive decline or early stages of cognitive decline, to implement interventions aimed at slowing the progression to dementia.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Cardiology and Cardiovascular Medicine

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