Affiliation:
1. Department of Pathology and Laboratory Medicine Larner College of Medicine University of Vermont Burlington VT
2. Department of Epidemiology University of Washington Seattle WA
3. Department of Biostatistics School of Public Health University of Alabama at Birmingham AL
4. Department of Epidemiology School of Public Health University of Alabama at Birmingham AL
5. Department of Medicine Larner College of Medicine University of Vermont Burlington VT
Abstract
Background
Soluble
CD
14 (
sCD
14), a circulating pattern recognition receptor, has been suggested as a cardiovascular disease risk factor. Prospective studies evaluating
sCD
14 with incident cardiovascular disease events are limited, particularly among racially diverse populations.
Methods and Results
Between 2003 and 2007, the
REGARDS
(
Re
asons for Geographic and Racial Differences in Stroke) study recruited 30 239 black and white participants across the United States. In a nested case–cohort study,
sCD
14 was measured in baseline serum from 548 cases of incident ischemic stroke, 612 cases of incident coronary heart disease (
CHD
), and a cohort random sample (n=1039). Cox models estimated hazards ratios (
HR
) of incident ischemic stroke or
CHD
per 1
SD
higher
sCD
14, adjusting for cardiovascular disease risk factors. There was a differential association of
sCD
14 with ischemic stroke and
CHD
risk by race. Among blacks, the adjusted
HR
of stroke per
SD
increment of
sCD
14 was 1.42 (95%
CI
: 1.12, 1.80), with no association among whites (
HR
1.02 [95%
CI
: 0.82, 1.27]). Higher
sCD
14 was associated with increased
CHD
risk in blacks but not whites, and relationships between
sCD
14 and
CHD
were stronger at younger ages. Adjusted for risk factors, the
HR
of
CHD
per
SD
higher
sCD
14 among blacks at age 45 years was 2.30 (95%
CI
: 1.45, 3.65) compared with 1.56 (95%
CI
: 0.94, 2.57) among whites. At age 65 years, the
CHD HR
was 1.51 (95%
CI
: 1.20, 1.91) among blacks and 1.02 (95%
CI
: 0.80, 1.31) among whites.
Conclusions
sCD
14 may be a race‐specific stroke and
CHD
risk marker.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Cardiology and Cardiovascular Medicine
Cited by
12 articles.
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