Incidental Congestive Heart Failure in Patients With Aldosterone‐Producing Adenomas-Reference-Cited by-同舟云学术

Incidental Congestive Heart Failure in Patients With Aldosterone‐Producing Adenomas

Published:2019-12-17 Issue:24 Volume:8 Page:
ISSN:2047-9980
Container-title:Journal of the American Heart Association
language:en
Short-container-title:JAHA

Author:

Huang Wei‐Chieh¹²³,Chen Ying‐Ying⁴⁵,Lin Yen‐Hung⁶,Chen Likwang⁷,Lin Po‐Chih⁶,Lin Yu‐Feng⁶,Liu Yu‐Chun⁸,Wu Che‐Hsiung⁹¹⁰,Chueh Jeff S.¹¹,Chu Tzong‐Shinn⁶,Wu Kwan Dun⁵⁶,Huang Chun‐Yao⁹¹⁰¹²¹³¹⁴,Wu Vin‐Cent⁵⁶,Lai Tai‐Shuan,Yang Shao‐Yu,Liu Kao‐Lang,Chang Chin‐Chen,Lee Bo‐Chiag,Wang Shuo‐Meng,Huang Kuo‐How,Lin Lian‐Yu,Liao Shih‐Cheng,Yen Ruoh‐Fang,Lu Ching‐Chu,Chan Chieh‐Kai,Er Leay‐Kiaw,Hu Ya‐Hui,Chang Chia‐Hui,Tsai Yao‐Chou,Ho Chen‐Hsun

Affiliation:

1. Division of Cardiology Department of Internal Medicine Taipei Veterans General Hospital Taipei Taiwan, R.O.C

2. School of Medicine National Yang‐Ming University Taipei Taiwan, R.O.C

3. Division of Cardiology Department of Internal Medicine New Taipei City Hospital New Taipei City Taiwan

4. Division of Nephrology Department of Internal Medicine MacKay Memorial Hospital Taipei Taiwan

5. Graduate Institute of Clinical Medicine College of Medicine National Taiwan University Hospital Taipei Taiwan

6. Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan

7. Institute of Population Health Sciences National Health Research Institutes Zhunan Taiwan

8. Far Eastern Polyclinic of Far Eastern Medical Foundation Taipei City Taiwan

9. Division of Nephrology Taipei Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Taipei Taiwan

10. School of Medicine Tzu Chi University Hualien, Taipei Taiwan

11. Glickman Urological and Kidney Institute, and Cleveland Clinic Lerner College of Medicine Cleveland Clinic Cleveland OH

12. Division of Cardiology and Cardiovascular Research Center Department of Internal Medicine Taipei Medical University Hospital Taipei Taiwan

13. Division of Cardiology Department of Internal Medicine School of Medicine College of Medicine Taipei Medical University Taipei Taiwan

14. Taipei Heart Institute Taipei Medical University Hospital Taipei Taiwan

Abstract

Background Previous studies show that patients with primary aldosteronism are associated with higher risk of congestive heart failure ( CHF ). However, the effect of target treatment to the incidental CHF has not been elucidated. We aimed to investigate the risk of new‐onset CHF in patients with aldosterone‐producing adenomas ( APAs ) and explore the effect of adrenalectomy on new onset of CHF . Methods and Results From 1997 to 2009, 688 APA were identified and matched with essential hypertension controls. The risks of developing incidental CHF (hazard ratio, 0.49; 95% CI , 0.31–0.75; P =0.001) and mortality (hazard ratio, 0.29; 95% CI , 0.20–0.44; P <0.001) were significantly lower in the APA group after targeted treatment. A total of 605 patients with APAs who underwent adrenalectomy lowered the risks of CHF (subdistribution hazard ratio, 0.55; 95% CI , 0.34–0.90; P =0.017) and mortality (adjusted hazard ratio, 0.27; 95% CI , 0.16–0.44; P <0.001) compared with essential hypertension controls. Conclusions In conclusion, for patients with APAs, adrenalectomy can be associated with lower risk of incidental CHF and all‐cause mortality in a long‐term follow‐up.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Cardiology and Cardiovascular Medicine

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