Affiliation:
1. Department of Epidemiology and Public Health Graduate School of Medical Sciences Kyushu University Fukuoka Japan
2. Department of Anesthesiology and Critical Care Medicine Graduate School of Medical Sciences Kyushu University Fukuoka Japan
3. Department of Medicine and Clinical Science Graduate School of Medical Sciences Kyushu University Fukuoka Japan
4. Center for Cohort Studies Graduate School of Medical Sciences Kyushu University Fukuoka Japan
5. Research Institute Suntory Global Innovation Center Ltd Kyoto Japan
Abstract
Background
Epidemiological studies have reported a link between serum LBP (lipopolysaccharide‐binding protein) levels and lifestyle‐related diseases. However, there have been no longitudinal studies investigating the association of serum
LBP
levels and the incidence of cardiovascular disease (
CVD
) in general populations.
Methods and Results
A total of 2568 community‐dwelling Japanese individuals 40 years and older without prior
CVD
were followed for 10 years (2002–2012). Serum
LBP
levels were divided into quartiles (quartile 1: 2.20–9.68 μg/mL; quartile 2: 9.69–10.93 μg/mL; quartile 3: 10.94–12.40 μg/mL; quartile 4: 12.41–24.34 μg/mL). The hazard ratios (
HR
s) and their 95%
CI
s for the incidence of
CVD
were computed using a Cox proportional hazards model. During the follow‐up period, 180 individuals developed
CVD
. The age‐ and sex‐adjusted cumulative incidence of
CVD
increased significantly with higher serum
LBP
levels (
P
for trend=0.005). Individuals with higher serum
LBP
levels had a significantly greater risk of the development of
CVD
after adjusting for conventional cardiovascular risk factors (quartile 1: HR, 1.00 [reference]; quartile 2: HR, 1.04 [95% CI, 0.60–1.78]; quartile 3: HR, 1.52 [95% CI, 0.92–2.51]; and quartile 4: HR, 1.90 [95% CI, 1.17–3.09];
P
for trend=0.01). This association remained significant after additional adjustment for homeostasis model assessment of insulin resistance (
P
for trend=0.01). However, when additional adjustment was made for high‐sensitivity C‐reactive protein, the association was attenuated to the nonsignificant level (
P
for trend=0.08).
Conclusions
The present findings suggest that higher serum
LBP
levels are associated with increased risk of the development of
CVD
in the general Japanese population. Low‐grade endotoxemia may contribute to the pathogenesis of
CVD
through chronic systemic inflammation.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Cardiology and Cardiovascular Medicine
Cited by
34 articles.
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