Affiliation:
1. Department of Medicine University of British Columbia Vancouver BC Canada
2. Centre for Heart Lung Innovation University of British Columbia Vancouver BC Canada
3. BC Centre for Improved Cardiovascular Health Vancouver BC Canada
4. Center for Health Evaluation and Outcomes Science University of British Columbia Vancouver BC Canada
Abstract
Background
The incidence of atherosclerotic cardiovascular disease has declined in the past 2 decades. However, these benefits may not extend to young patients. The objective of this work was to assess temporal trends in the incidence, risk profiles, sex‐related differences, and outcomes in a contemporary population of young patients presenting with coronary artery disease (
CAD
) in British Columbia, Canada.
Methods and Results
We used a provincial cardiac registry to identify young patients (men aged <50 years, women aged <55 years), with a first presentation of
CAD
between 2000 and 2016, who had either ≥50% stenosis of ≥1 coronary arteries on angiography or underwent coronary revascularization. A total of 12 519 patients (30% women) met our inclusion criteria. The incidence of
CAD
remained stable and was higher for men than women (46–53 versus 18–23 per 100 000). Of patients, 92% had at least one traditional cardiovascular risk factor and 67% had multiple risk factors. The prevalence of diabetes mellitus, obesity, and hypertension increased during the study period and was higher for women. Women had fewer emergent procedures and revascularizations. Mortality rates decreased by 31% between 2000 and 2007, then were stable for the remaining 9 years. Mortality was significantly higher for women aged <45 years compared with men.
Conclusions
The incidence of premature
CAD
has not declined, and the prevalence of 3 major cardiovascular risk factors increased between 2000 and 2016. The risk burden and mortality rates were worse for women. These data have important implications for the design of strategies to prevent
CAD
in young adults.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Cardiology and Cardiovascular Medicine
Cited by
70 articles.
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