Affiliation:
1. Department of Cardiology Herlev and Gentofte Hospital University of Copenhagen Denmark
2. The Copenhagen City Heart Study Frederiksberg Hospital Frederiksberg Denmark
3. Department of Biomedical Sciences Faculty of Health and Medical Sciences University of Copenhagen Denmark
Abstract
Background
Cardiovascular disease remains a leading cause of death. Right ventricular (
RV
) function is a strong predictor of outcome in many cardiovascular diseases, but its significance is often neglected. Little is known about the prognostic value of
RV
systolic function in the general population. Therefore, we aimed to determine the prognostic value of
RV
systolic function, evaluated by tricuspid annular plane systolic excursion (
TAPSE
), in predicting cardiovascular death (
CVD
) in the general population.
Methods and Results
A total of 1039 participants from the general population without heart failure or atrial fibrillation had an echocardiogram performed and
TAPSE
measured. The end point was
CVD
. During a median follow‐up of 12.7 years (interquartile range, 12.0–12.9 years), 69 participants (6.6%) experienced
CVD
, whereas 162 participants (15.6%) experienced non‐CVD. Decreasing
RV
systolic function, assessed as
TAPSE
, was a univariable predictor of
CVD
(hazard ratio, 1.13; 95%
CI
, 1.07–1.20;
P
<0.001, per 1‐mm decrease).
TAPSE
remained an independent predictor of
CVD
after adjusting for clinical and echocardiographic parameters (hazard ratio, 1.08; 95%
CI
, 1.01–1.15;
P
=0.017, per 1‐mm decrease). Furthermore, in net reclassification analysis, decreasing
RV
systolic function, assessed as
TAPSE,
significantly improved risk classification with respect to
CVD
when added to established cardiovascular risk factors from the Systematic Coronary Risk Evaluation chart or a modified version of the American Heart Association/American College of Cardiology Pooled Cohort Equation. Decreasing
RV
systolic function, assessed as
TAPSE
, did not predict non‐CVD, indicating specificity for
CVD
.
Conclusions
RV
systolic function, as assessed by
TAPSE
, is associated with
CVD
in the general population. In the general population, assessment of
RV
systolic function may provide novel prognostic information about the risk of
CVD
.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Cardiology and Cardiovascular Medicine
Cited by
44 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献