Effect of pH Change upon Renal Vascular Resistance and Urine Flow

Abstract

In the dog kidney, acute increase and decrease in hydrogen ion concentration results in decrease and increase in renal vascular resistance respectively. These changes occur predominantly on the alkaline side of pH 7.3 and result from some direct effect upon vascular smooth muscle. The re sistance changes are less apparent in nerve intact than nerve sectioned kidneys due to opposing effects mediated through extrinsic nerves.