1. From the Department of Cardiovascular Medicine, Catholic University of the Sacred Heart, Rome, Italy (A.M.L., A.R.D.C., E.B., A.G., D.L., M.A.M., R.M., I.P., G.N., F.B., C.T., A.G.R., F.C.); and Department of Cardiovascular Medicine, John Radcliffe Hospital, Oxford, UK (R.K., F.C., A.P.B.).