Author:
Husain A,Bumpus F M,Smeby R R,Brosnihan K B,Khosla M C,Speth R C,Ferrario C M
Abstract
A family of angiotensin I-like peptides has been derived from endogenous precursors present in dog cerebrospinal fluid after incubation with species homologous renin. These peptides are immunologically and pharmacologically similar to [Ile5]angiotensin I, and have molecular weights ranging between 1300 and 2200 daltons. The presence of precursors in the cerebrospinal fluid able to generate various biologically active angiotensin I-like peptides dissimilar to plasma angiotensin I supports the concept of a local angiotensin I-forming system in the brain.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Cardiology and Cardiovascular Medicine,Physiology
Reference28 articles.
1. A MICROMETHOD FOR MEASUREMENT OF RENIN IN THE PLASMA AND KIDNEY OF RATS
2. Effects of chronic sodium depletion on canine brain renin and cathepsin D activities.
3. Buckley JP Ferrario CM (1977) Central actions of angiotensin and Related Hormones. New York Pergamon Press
4. Primary structure of the human Met- and Leu-enkephalin precursor and its mRNA
5. Dimaline RS Dockray GJ (1982) Molecular forms of VIP in normal tissue. In Vasoactive Intestinal Peptide edited by SI Said. New York Raven Press pp 23-33
Cited by
22 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献