Affiliation:
1. Clinic of Cardiology St. Olavs University Hospital Trondheim Norway
2. Department of Circulation and Medical Imaging Norwegian University of Science and Technology Trondheim Norway
3. National Advisory Unit on Exercise Training as Medicine for Cardiopulmonary Conditions Trondheim Norway
4. Department of Clinical and Molecular Medicine Norwegian University of Science and Technology Trondheim Norway
5. School of Human Movement and Nutrition Science University of Queensland Australia
Abstract
Background
The effect of physical exercise on lipid content of coronary artery plaques is unknown. With near infrared spectroscopy we measured the effect of high intensity interval training (HIIT) on lipid content in coronary plaques in patients with stable coronary artery disease following percutaneous coronary intervention.
Methods and Results
In CENIT (Impact of Cardiac Exercise Training on Lipid Content in Coronary Atheromatous Plaques Evaluated by Near‐Infrared Spectroscopy) 60 patients were randomized to 6 months supervised HIIT or to a control group. The primary end point was change in lipid content measured as maximum lipid core burden index at 4 mm (maxLCBI
4mm
). A predefined cutoff of maxLCBI
4mm
>100 was required for inclusion in the analysis. Forty‐nine patients (HIIT=20, usual care=29) had maxLCBI
4mm
>100 at baseline. Change in maxLCBI
4mm
did not differ between groups (−1.2, 95% CI, −65.8 to 63.4,
P
=0.97). The estimated reduction in maxLCBI
4mm
was −47.7 (95% CI, −100.3 to 5.0,
P
=0.075) and −46.5 (95% CI, −87.5 to −5.4,
P
=0.027) after HIIT and in controls, respectively. A negative correlation was observed between change in peak oxygen uptake (VO
2peak
) and change in lipid content (Spearman’s correlation −0.44,
P
=0.009). With an increase in VO
2peak
above 1 metabolic equivalent task, maxLCBI
4mm
was on average reduced by 142 (−8 to −262), whereas the change was −3.2 (154 to −255) with increased VO
2peak
below 1 metabolic equivalent task.
Conclusions
Six months of HIIT following percutaneous coronary intervention did not reduce lipid content in coronary plaques compared with usual care. A moderate negative correlation between increase in VO
2peak
and change in lipid content generates the hypothesis that exercise with a subsequent increase in fitness may reduce lipid content in coronary atheromatous plaques.
Registration
URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT02494947.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Cardiology and Cardiovascular Medicine
Cited by
9 articles.
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