Affiliation:
1. From the Center for Medical Research (S.P.S., A.G.) and Department of Obstetrics and Gynecology (S.P.S.), School of Medicine; and Department of Physiology (C.P.V.), Faculty of Biological Sciences, Pontificia Universidad Católica de Chile.
Abstract
Water-retaining hormones are stimulated during pregnancy allowing normal volume expansion. Because pregnant rats actively retain water, we postulate that water deprivation (WD) would cause a greater reduction in plasma volume in pregnant than in nonpregnant rats. To test this hypothesis, Sprague-Dawley pregnant and nonpregnant rats were water-deprived for 48 hours. At day 19 of pregnancy, or in the corresponding day in nonpregnant rats, they were randomly assigned to either a WD or a control (C) pair-fed group (n=10 to 12 per group). WD significantly reduced body weight, food intake, and creatinine clearance, and increased urinary osmolality in nonpregnant and pregnant rats. WD reduced plasma volume in a similar proportion in nonpregnant and pregnant rats (nonpregnant rats C=13.1±0.4, WD=11.0±0.2; pregnant rats C=19.4±0.7, WD=16.8±0.5 mL,
P
<0.001). Both groups of pregnant rats had a similar reduction in blood pressure. Plasma renin activity (nonpregnant rats C=6.1±1.1, WD=20.5±2.0; pregnant rats C=49±9.7, WD=94±12 ng angiotensin I/mL per hour,
P
<0.001) and plasma aldosterone levels were increased by pregnancy and further increased by WD. WD significantly reduced urinary kallikrein. WD caused a significant reduction in fetal but not placental weights. Present data indicate that 48-hour WD reduced renal kallikrein and further stimulated water-retaining hormones. We speculate that these are compensatory changes contributing to the maintenance of pregnancy in response to WD.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Cited by
12 articles.
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