1. From Department of Pharmacology (A.N., L.Y., T.S., S.K., Y.A.), Research Equipment Center (Y.N.), RI Research Center (K.M.), and Second Department of Internal Medicine (H.K., M.K.), Kagawa Medical University, Kagawa, Japan; Departments of Pharmacology (M.Y.) and Pediatrics (S.K., S.Ko.), University of Tokushima School of Medicine, Tokushima, Japan.