1. From the Department of Pharmacology, Institute of Biomedical Sciences, University of Sao Paulo (G.E.C., S.A.T., M.N.M., M.H.C.C., Z.B.F., D.N., R.C.T.), Sao Paulo, Brazil, and Clinical Research Institute of Montreal, University of Montreal (R.M.T., E.L.S.), Montreal, Canada.