1. From the Departments of Medicine (L.N., D.E.L.) and Clinical Chemistry (K.P.), Kuopio University Hospital, Finland; Research Institute of Public Health (K.N., V-P.V., T-P.T., J.T.S.) and Department of Public Health and General Practice (R.S.), University of Kuopio, Finland; and Jurilab Ltd (R.F., J.T.S.), Kuopio, Finland.