1. From the Departments of Pharmacology (J.J.S., I.M.G., A.H.J.D.) and Biochemistry (D.H.W.D., J.M.J.L.), Erasmus MC, Rotterdam, The Netherlands; the Center for Human and Clinical Genetics (P.A.C.t.H., J.T.d.D.), and the Leiden Genome Technology Center (J.T.d.D.), Leiden University Medical Center, Leiden, The Netherlands.