1. From the Framingham Heart Study of the National Heart Lung and Blood Institute and Boston University School of Medicine (C.N.-C., C.-Y.G., P.G., M.G.L., E.J.B., T.J.W., S.K., C.J.O., D.L., R.S.V.), Framingham, Mass; the Broad Institute of Harvard and Massachusetts Institute of Technology (C.N.-C., S.K., S.L.M., A.L.C., J.A.D., J.N.H.), Cambridge; the Cardiology Division (C.N.-C., T.J.W., S.K., C.O.D.), Massachusetts General Hospital, Boston; the Department of Mathematics and Statistics (C.-Y.G., P.G...