1. From the Department of Geriatric Medicine (T.K., N.I., M.I., M.K., Y.T., A.S., H.R., T.O.), Osaka University Graduate School of Medicine, Suita; Institute of Medical Science (S.S.), University of Tokyo; and the Otsuka GEN Research Institute (S.T.), Otsuka Pharmaceutical Co. Ltd, Tokushima, Japan.