1. From the Department of Pharmacology (J.H.M.v.E., B.T., W.W.B., R.d.V., A.H.J.D.) and Internal Medicine (J.M.G.v.G., R.J.A.d.B.), Erasmus MC, Rotterdam, The Netherlands; CEA (V.D.), Départment d’Ingénierie et d’Etudes des Protéines, CE-Saclay, France; and Department of Organic Chemistry (D.G., A.Y.), Laboratory of Organic Chemistry, University of Athens, Panepistimiopolis, Zografou, Greece.