1. From the Department of Clinical Pharmacology (N.W., A.D.H., N.C., R.E., M.M., S.A.M.T.), National Heart and Lung Institute Division, International Centre for Circulatory Health, Faculty of Medicine, Imperial College London, United Kingdom; Centre for Eye Research Australia (T.Y.W.), University of Melbourne, Australia; and Department of Ophthalmology and Visual Sciences (B.E.K., R.K.), University of Wisconsin Medical School, Madison.