1. From the Tohoku University 21st Century Center of Excellence Program Comprehensive Research and Education Center for Planning of Drug Development and Clinical Evaluation “CRESCENDO” (R.I., T.O., H.M., K.A., J.H., K.T., H.S., Y.K., Y.I.), Department of Clinical Pharmacology and Therapeutics (H.M., K.A., T.O., K.T., Y.I.), and Drug Development and Clinical Evaluation (T.O., M.K., J.H.), Environmental Health Sciences (H.S.), Tohoku University Graduate School of Pharmaceutical Science and Medicine,...