Prevention of experimental subarachnoid hemorrhage-induced intracranial arterial vasonecrosis with phosphodiesterase inhibitor phthalazinol (EG-626).-Reference-Cited by-同舟云学术

Prevention of experimental subarachnoid hemorrhage-induced intracranial arterial vasonecrosis with phosphodiesterase inhibitor phthalazinol (EG-626).

Published:1979-11 Issue:6 Volume:10 Page:638-644
ISSN:0039-2499
Container-title:Stroke
language:en
Short-container-title:Stroke

Author:

Alksne J F,Branson P J

Abstract

Experiments in monkeys have demonstrated that the chronic vasospasm and arterial injury reaction produced by subarachnoid blood injection can be prevented by treatment with the phosphodiesterase inhibitor phthalazinol. This protective effect, which is present even when the drug treatment is initiated after the subarachnoid blood injection, is presumed to occur because of the platelet inhibiting effect of phthalazinol.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Advanced and Specialised Nursing,Cardiology and Cardiovascular Medicine,Clinical Neurology

Link

https://www.ahajournals.org/doi/pdf/10.1161/01.STR.10.6.638

Reference24 articles.

1. Wilkins RH: Attempts at treatment of intracranial don New York Plenum Press 1974

2. Adachi K Numano F: Phosphodiesterase inhibitors: Their

3. arterial comparative effectiveness in vitro in various organs. Jpn J Phar

4. in animals and human beings;Surg Neurol

5. 1973

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