The Relation Between Cardiac Function and Cerebral Blood Flow in Stroke Patients. 1. Effect of CO2Inhalation

Abstract

The effects of CO2inhalation were determined on 23 stroke patients with and without hypertension who underwent clinical, cardiohemodynamic, cerebral blood flow (hemispheric mean and regional), cerebral metabolic rate and cerebral angiographical studies.Cardiac output, heart rate, systemic and pulmonary arterial blood pressures and cardiac work rose in essentially all patients during CO2inhalation, and fell to below baseline levels in approximately half of the patients studied after CO2, inhalation was discontinued.Baseline cardiac output was normal in normotensive stroke patients without cardiac dysfunction, but was low in hypertensive stroke patients.A statistically significant increase in cerebral blood flow occurred during CO2, inhalation, with an observed decrease in cerebrovascular resistance. The percentage increase in cerebral blood flow exceeded the increase in cardiac output.Since hypercarbia causes a rise in systemic and pulmonary arterial blood pressure, CO2inhalation should be used cautiously in patients with systemic or pulmonary hypertension. The rise in cardiac work during CO2inhalation could jeopardize patients with coronary heart disease and those with heart failure.Following cessation of CO2inhalation, blood pressure and cardiac output may fall below baseline levels, with a risk of posthypercapnic fall in cerebral blood flow. Occasionally, cardiac arrhythmia occurs during or following CO2inhalation.