Author:
Hawkins R,Hass W K,Ransohoff J
Abstract
A new technique is described for the autoradiographic determination of regional brain glucose metabolism employing 14C labeled glucose as substrate and measurement principles previously described for whole brain. Regional glucose values correlate closely with those reported for the 14C-deoxyglucose technique. The method has the advantages of 1) a much shorter experimental period, 2) a relatively simple mathematical treatment, and 3) the utilization of the actual, fully metabolizable substance itself, glucose, as the label. In addition to normal rats, regional values are reported for 20 individual brain areas of rats in bicuculline induced status epilepticus, rats intoxicated with ammonium and rats anesthetized with pentobarbital sodium or ketamine.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Advanced and Specialised Nursing,Cardiology and Cardiovascular Medicine,Clinical Neurology
Reference63 articles.
1. Siesjo' BK: Brain Energy Metabolism New York John Wiley & Sons pp 29-100 1978
2. RELATION BETWEEN PHYSIOLOGICAL FUNCTION AND ENERGY METABOLISM IN THE CENTRAL NERVOUS SYSTEM
3. RATE OF UTILIZATION OF GLUCOSE AND ‘COMPARTMENTATION’ OF α-OXOGLUTARATE AND GLUTAMATE IN RAT BRAIN
4. Balazs R: Carbonhydrate metabolism. In Lajtha CA (ed) Handbook of Neurochemistry. New York Plenum Press Vol III pp 1-36 1970
5. Sacks W: Cerebral metabolism in vivo. In Lajtha A (ed) Handbook of Neurochemistry. New York Plenum Press Vol 3 1970
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