Author:
Hoffman W E,Albrecht R F,Miletich D J
Abstract
Cerebrovascular effects of intravenous (iv) nitroglycerin (NTG) infusions were tested in four month old spontaneously hypertensive rats (SHR) and Wistar Kyoto controls (WKY). Cerebral blood flow (CBF) changes were measured during iv NTG infusion in ventilated, halothane anesthetized rats using radioactive microspheres. In control WKY rats given isotonic saline infusions instead of NTG, blood pressure and CBF did not change over 3 microsphere injections. When blood pressure was decreased to 65 and then 45 torr with iv NTG infusions, CBF was maintained or increased in both SHR and WKY. There was no difference in response between SHR and WKY. These results support other reports that NTG has direct cerebrovasodilating effects, and indicate that this action will maintain adequate CBF in hypertensive as well as normotensive subjects to pressures below 50 torr.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Advanced and Specialised Nursing,Cardiology and Cardiovascular Medicine,Clinical Neurology
Reference33 articles.
1. Stone HH Mackrell TN Wechsler RL: The effect on cerebral
2. circulation and metabolism in man of acute reduction in blood
3. pressure by means of intravenous hexamethonium bromide and
4. head-up tilt. Anesthesiology 16: 168-176 1955
5. Strandgaard S Olsen J Skin^j E Lassen NA: Autoregulation
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