Localization of Radioisotope (Chlormerodrin Hg-203) in Experimental Cerebral Infarction-Reference-Cited by-同舟云学术

Localization of Radioisotope (Chlormerodrin Hg-203) in Experimental Cerebral Infarction

Published:1970-05 Issue:3 Volume:1 Page:143-148
ISSN:0039-2499
Container-title:Stroke
language:en
Short-container-title:Stroke

Author:

DUDLEY ALDEN W.¹,LUNZER STEVEN²,HEYMAN ALBERT²

Affiliation:

1. Department of Pathology, University of Wisconsin, Madison, Wisconsin, 53706

2. Divisions of Neuropathology and Neurology and the Center of Cerebrovascular Research, Duke University School of Medicine, Durham, North Carolina

Abstract

A combined histological and radioautographical study was made to determine the mechanism for the selective localization of Hg-203-labelled Chlormerodrin in the brain of 13 cats with experimentally induced cerebral infarction. The presence of the radioactive tracer in the infarcted areas was noted within a few days after the onset of the lesions and was increased by hemorrhage into the tissues. The radioautograms revealed the radioactive material to be localized mostly within macrophages and in areas surrounding capillary proliferation. These two pathoanatomic processes associated with necrosis of the cerebral tissues most likely account for the abnormal accumulation of radionuclide tracer in brain scans of patients with cerebral infarction.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Advanced and Specialized Nursing,Cardiology and Cardiovascular Medicine,Neurology (clinical)

Link

https://www.ahajournals.org/doi/pdf/10.1161/01.STR.1.3.143

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5. Brain Vascular Permeability to I125Gamma Globulin and Leukocytes in Allergic Encephalomyelitis*†

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