1. From the British Heart Foundation/University of Edinburgh Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK (G.D.B., S.A., C.M.P., K.M.L., T.J.H., S.V., H.J., A.W., D.E.N.); Edinburgh Heart Centre, Royal Infirmary of Edinburgh, Edinburgh, UK (A.G.J., N.L.C., D.E.N.); and Department of Experimental Medicine, Imperial College, London, UK (L.H.).