1. From the Department of Physiology, Temple University School of Medicine, Philadelphia, PA (G.M., J.C.P., G.G., F.W., A.L., L.L., C.A.M., R.M., S.R.H., F.A.R.); Department of Medical Sciences, University of Turin, Turin, Italy (F.S., L.T., R.G.); and Institute of Life Sciences, Scuola Superiore Sant’Anna, Pisa, Italy (F.A.R.).