Toward a Universal Definition of Etiologies in Heart Failure: Categorizing Causes and Advancing Registry Science

Author:

Agarwal Anubha1ORCID,Tromp Jasper2ORCID,Almahmeed Wael3,Angermann Christiane4ORCID,Chandramouli Chanchal5ORCID,Cho Hyunjai6,Choi Don-Ju6ORCID,Damasceno Albertino7ORCID,Filippatos Gerasimos8ORCID,Fonarow Gregg C.9ORCID,Harikrishnan Sivadasanpillai10ORCID,Lund Lars11ORCID,Masoudi Fred12ORCID,Mensah George A.13ORCID,Pathan Asad14,Perel Pablo15ORCID,Pinto Fausto16ORCID,Ribeiro Antonio Luiz17ORCID,Rich Stuart18ORCID,Sakata Yasuhiko1920,Sliwa Karen21ORCID,Sundstrom Johan22ORCID,Wong Renee23ORCID,Yancy Clyde18ORCID,Yiu Kelvin24ORCID,Zhang Jian25ORCID,Zhang Yuhui25ORCID,Lam Carolyn S.P.2627ORCID,Roth Gregory A.28ORCID,

Affiliation:

1. Washington University in St. Louis School of Medicine, MO (A.A.).

2. Saw Swee Hock School of Public Health, National University of Singapore and National University Health System (J.T.).

3. Heart and Vascular Institute, Cleveland Clinic, Abu Dhabi, United Arab Emirates (W.A.).

4. Comprehensive Heart Failure Center, University Hospital Wuerzburg, Germany (C.A.).

5. National Heart Centre Singapore and Duke-NUS Medical School (C.C.).

6. Seoul National University Hospital, Korea (H.C., D.-J.C.).

7. Eduardo Mondlane University, Maputo, Mozambique (A.D.).

8. University of Cyprus, School of Medicine and National and Kapodistrian University of Athens, School of Medicine, Department of Cardiology, Attikon University Hospital, Greece (G.F.).

9. Ronald Reagan UCLA Medical Center, Los Angeles, CA (G.C.F.).

10. Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, Kerala, India (S.H.).

11. Karolinska University Hospital, Stockholm, Sweden (L.L.).

12. University of Colorado School of Medicine at the Anschutz Medical Campus, Aurora (F.M.).

13. Center for Translation Research and Implementation Science, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD (G.A.M.).

14. Tabba Heart Institute Karachi, Pakistan (A.P.).

15. London School of Hygiene and Tropical Medicine, United Kingdom (P.P.).

16. Santa Maria University Hospital, University of Lisbon, Portugal (F.P.).

17. Hospital das Clinicas and School of Medicine, Unversidade Federal de Minas Gerais, Belo Horizonte, Brazil (A.L.R.).

18. Northwestern University Feinberg School of Medicine, Chicago, IL (S.R., C.Y.).

19. Tohoku University Graduate School of Medicine, Sendai, Japan (Y.S.).

20. National Cerebral and Cardiovascular Center, Suita, Japan (Y.S.).

21. University of Cape Town, South Africa (K.S.).

22. Uppsala University, Sweden (J.S.).

23. Heart Failure and Arrhythmias Branch, Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD (R.W.).

24. Institute of Cardiovascular Science and Medicine, Hong Kong University, Hong Kong and Department of Medicine, University of Hong Kong-Shenzhen Hospital, China (K.Y.).

25. Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (J.Z., Y.Z.).

26. National Heart Centre Singapore, Singapore (C.S.P.L.).

27. Duke-NUS Medical School, Singapore and University Medical Centre Groningen, the Netherlands (C.S.P.L.).

28. University of Washington, Seattle (G.A.R.).

Abstract

Heart failure (HF) is a well-described final common pathway for a broad range of diseases however substantial confusion exists regarding how to describe, study, and track these underlying etiologic conditions. We describe (1) the overlap in HF etiologies, comorbidities, and case definitions as currently used in HF registries led or managed by members of the global HF roundtable; (2) strategies to improve the quality of evidence on etiologies and modifiable risk factors of HF in registries; and (3) opportunities to use clinical HF registries as a platform for public health surveillance, implementation research, and randomized registry trials to reduce the global burden of noncommunicable diseases. Investment and collaboration among countries to improve the quality of evidence in global HF registries could contribute to achieving global health targets to reduce noncommunicable diseases and overall improvements in population health.

Publisher

Ovid Technologies (Wolters Kluwer Health)

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