Characteristics of Phrenic Nerve Injury During Pulmonary Vein Isolation Using a 28‐mm Second‐Generation Cryoballoon and Short Freeze Strategy

Author:

Miyazaki Shinsuke1,Kajiyama Takatsugu2,Watanabe Tomonori2,Hada Masahiro2,Yamao Kazuya2,Kusa Shigeki2,Igarashi Miyako2,Nakamura Hiroaki2,Hachiya Hitoshi2,Tada Hiroshi1,Hirao Kenzo3,Iesaka Yoshito2

Affiliation:

1. Department of Cardiovascular Medicine, Fukui University, Fukui, Japan

2. Cardiovascular Center, Tsuchiura Kyodo Hospital, Tsuchiura, Ibaraki, Japan

3. Heart Rhythm Center, Tokyo Medical and Dental University, Tokyo, Japan

Abstract

Background The reported incidence of phrenic nerve injury ( PNI ) varies owing to different definitions, balloon generations, balloon size, freezing regimen, and protective maneuvers. We evaluated the incidence, predictors, and outcome of PNI during cryoballoon pulmonary vein isolation in a large population. Methods and Results Five hundred fifty atrial fibrillation patients underwent pulmonary vein isolation using one 28‐mm second‐generation cryoballoon and single 3‐minute freeze strategy under diaphragmatic compound motor action potential ( CMAP ) monitoring. A total of 34 (6.2%) patients experienced PNI during the right superior and inferior pulmonary vein ablation in 30 and 4 patients, respectively. Applications were interrupted using double‐stop techniques after 136 [104–158] second applications, and a pulmonary vein isolation was already achieved in all but one case. The baseline CMAP amplitude and timing of deflation ( CMAP def ) were 0.75±0.30 and 0.17±0.17 mV, respectively. Persistent atrial fibrillation , larger right superior pulmonary vein ostia, and deeper balloon positions were associated with higher incidences of PNI . The CMAP def predicted a PNI recovery delay, and the best cutoff value for predicting PNI recovery by the next day was 0.20 mV (sensitivity 57.1%, specificity 100%). Among 6 patients undergoing second procedures 8.5 (6.7–15.0) months later, the right superior pulmonary vein was durable in 3 with >120 second applications. Despite active balloon deflation, no significant pulmonary vein stenosis was observed in 15 right superior pulmonary vein s evaluated 6 (5–9) months later. No patients had symptoms, and the PNI recovered 1 day and 1 month postprocedure in 21 and 4 patients, respectively. Conclusions PNI resulting from cryoballoon ablation was reversible. The double‐stop technique is safe, and immediate active deflation following a CMAP decrease appears to be essential for faster PNI recovery.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Cardiology and Cardiovascular Medicine

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