Kinome and Transcriptome Profiling Reveal Broad and Distinct Activities of Erlotinib, Sunitinib, and Sorafenib in the Mouse Heart and Suggest Cardiotoxicity From Combined Signal Transducer and Activator of Transcription and Epidermal Growth Factor Receptor Inhibition-Reference-Cited by-同舟云学术

Kinome and Transcriptome Profiling Reveal Broad and Distinct Activities of Erlotinib, Sunitinib, and Sorafenib in the Mouse Heart and Suggest Cardiotoxicity From Combined Signal Transducer and Activator of Transcription and Epidermal Growth Factor Receptor Inhibition

Published:2017-10-11 Issue:10 Volume:6 Page:
ISSN:2047-9980
Container-title:Journal of the American Heart Association
language:en
Short-container-title:JAHA

Author:

Stuhlmiller Timothy J.¹²,Zawistowski Jon S.¹²,Chen Xin¹²,Sciaky Noah¹²,Angus Steven P.¹²,Hicks Sean T.³,Parry Traci L.⁴³,Huang Wei³,Beak Ju Youn³,Willis Monte S.¹⁴³,Johnson Gary L.¹²,Jensen Brian C.¹⁵³

Affiliation:

1. Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, NC

2. Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC

3. University of North Carolina McAllister Heart Institute, Chapel Hill, NC

4. Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, NC

5. Division of Cardiology, University of North Carolina School of Medicine, Chapel Hill, NC

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Cardiology and Cardiovascular Medicine

Reference59 articles.

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2. The lack of target specificity of small molecule anticancer kinase inhibitors is correlated with their ability to damage myocytes in vitro

3. Sunitinib-Induced Cardiotoxicity Is Mediated by Off-Target Inhibition of AMP-Activated Protein Kinase

4. The dynamic nature of the kinome

5. Dynamic Reprogramming of the Kinome in Response to Targeted MEK Inhibition in Triple-Negative Breast Cancer

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