Genome Wide Association Study Identifies the HMGCS2 Locus to be Associated With Chlorthalidone Induced Glucose Increase in Hypertensive Patients

Author:

Singh Sonal1,McDonough Caitrin W.1,Gong Yan1,Alghamdi Wael A.1,Arwood Meghan J.1,Bargal Salma A.1,Dumeny Leanne1,Li Wen‐Yi1,Mehanna Mai1,Stockard Bradley1,Yang Guang1,de Oliveira Felipe A.1,Fredette Natalie C.2,Shahin Mohamed H.1,Bailey Kent R.3,Beitelshees Amber L.4,Boerwinkle Eric5,Chapman Arlene B.6,Gums John G.1,Turner Stephen T.7,Cooper‐DeHoff Rhonda M.18,Johnson Julie A.18

Affiliation:

1. Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, University of Florida, Gainesville, FL

2. Department of Pathology, Center of Regenerative Medicine, University of Florida, Gainesville, FL

3. Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, MN

4. Department of Medicine, University of Maryland, Baltimore, MD

5. Human Genetics and Institute of Molecular Medicine, University of Texas Health Science Center, Houston, TX

6. Section of Nephrology, University of Chicago, IL

7. Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN

8. Division of Cardiovascular Medicine, Department of Medicine, University of Florida, Gainesville, FL

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Cardiology and Cardiovascular Medicine

Reference51 articles.

1. Heart Disease and Stroke Statistics—2015 Update

2. Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population‐based measurement studies with 19.1 million participants;NCD Risk Factor Collaboration (NCD‐RisC);Lancet,2016

3. 2014 Evidence-Based Guideline for the Management of High Blood Pressure in Adults

4. Association of KCNJ1 variation with change in fasting glucose and new onset diabetes during HCTZ treatment

5. Impact of TCF7L2 single nucleotide polymorphisms on hydrochlorothiazide-induced diabetes

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