Affiliation:
1. From the Department of Haematology, Imperial College School of Medicine, Hammersmith Hospital, London, and the National Blood Service (F.E.B.), Southampton, UK.
Abstract
To investigate whether the effect of ABO blood group on plasma von Willebrand factor (vWF) levels is mediated by the
ABH
antigenic determinants carried on
N
-linked glycans of vWF, we studied 158 group A and group O healthy volunteers. vWF antigen (vWF:Ag) and factor VIII antigen (FVIII:Ag) levels were highest in
A
1
A
1
individuals and higher in
A
1
O
1
than in
A
2
O
1
or
O
1
O
1
individuals. Plasma
A
transferase
activity and the amount of
A
antigen expressed per unit vWF (
AvWF
) were significantly higher in
A
1
A
1
than in
A
1
O
1
individuals and higher in
A
1
O
1
than in
A
2
O
1
individuals.
AvWF
was correlated strongly with plasma levels of
A transferase
activity. Thus, we have clearly demonstrated a direct relationship between
ABO
genotype,
A transferase
expression, and the amount of
A
antigen expressed on circulating vWF.
H
antigen expression per unit vWF (
HvWF
) was highest in group O individuals. Among group A individuals, the pattern of
HvWF
expression was
A
2
O
1
>
A
1
O
1
>
A
1
A
1
. In group O and group
A
2
O
1
individuals,
HvWF
was inversely correlated with plasma vWF levels. In contrast, among group
A
1
A
1
and
A
1
O
1
individuals, there was no relationship between
AvWF
and plasma vWF levels. These findings suggest that it is
H
antigen expression that mediates the ABO effect on plasma vWF concentration.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Cardiology and Cardiovascular Medicine
Cited by
124 articles.
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