Genome-Wide Association Transethnic Meta-Analyses Identifies Novel Associations Regulating Coagulation Factor VIII and von Willebrand Factor Plasma Levels

Author:

Sabater-Lleal Maria12,Huffman Jennifer E.34,de Vries Paul S.56,Marten Jonathan7,Mastrangelo Michael A.8,Song Ci34,Pankratz Nathan9,Ward-Caviness Cavin K.10,Yanek Lisa R.11,Trompet Stella1213,Delgado Graciela E.14,Guo Xiuqing15,Bartz Traci M.16,Martinez-Perez Angel2,Germain Marine1718,de Haan Hugoline G.19,Ozel Ayse B.20,Polasek Ozren21,Smith Albert V.22,Eicher John D.4,Reiner Alex P.2324,Tang Weihong25,Davies Neil M.26,Stott David J.27,Rotter Jerome I.15,Tofler Geoffrey H.28,Boerwinkle Eric529,de Maat Moniek P.M.30,Kleber Marcus E.1431,Welsh Paul32,Brody Jennifer A.33,Chen Ming-Huei34,Vaidya Dhananjay11,Soria José Manuel2,Suchon Pierre3435,van Hylckama Vlieg Astrid19,Desch Karl C.36,Kolcic Ivana21,Joshi Peter K.37,Launer Lenore J.38,Harris Tamara B.38,Campbell Harry37,Rudan Igor37,Becker Diane M.11,Li Jun Z.20,Rivadeneira Fernando39,Uitterlinden André G.39,Hofman Albert640,Franco Oscar H.641,Cushman Mary42,Psaty Bruce M.23334344,Morange Pierre-Emmanuel3435,McKnight Barbara1645,Chong Michael R.46,Fernandez-Cadenas Israel47,Rosand Jonathan48,Lindgren Arne4950,Gudnason Vilmundur5152,Wilson James F.737,Hayward Caroline7,Ginsburg David20,Fornage Myriam553,Rosendaal Frits R.1954,Souto Juan Carlos55,Becker Lewis C.11,Jenny Nancy S.56,März Winfried145758,Jukema J. Wouter135459,Dehghan Abbas660,Trégouët David-Alexandre1718,Morrison Alanna C.5,Johnson Andrew D.34,O’Donnell Christopher J.3461,Strachan David P.62,Lowenstein Charles J.8,Smith Nicholas L.234463,

Affiliation:

1. Cardiovascular Medicine Unit, Department of Medicine, Karolinska Institutet, Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden (M.S.-L.).

2. Unit of Genomics of Complex Diseases, Institut d’Investigació Biomèdica Sant Pau, IIB-Sant Pau, Barcelona, Spain (M.S.-L., A.M.-P., J.M.S.).

3. Population Sciences Branch, National Heart, Lung, and Blood Institute, Framingham, MA (J.E.H., C.S., J.D.E., M.-H.C., A.D.J., C.J.O.).

4. Framingham Heart Study, MA (J.E.H., C.S., J.D.E., M.-H.C., A.D.J., C.J.O.).

5. Human Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health (P.S.d.V., E.B., M.F., A.C.M.), University of Texas Health Science Center at Houston.

6. Department of Epidemiology (P.S.d.V., A.H., O.H.F., A.D.), Erasmus University Medical Center, Rotterdam, the Netherlands.

7. Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine (J.M., J.F.W., C.H.), University of Edinburgh, Scotland.

8. Aab Cardiovascular Research Institute, University of Rochester Medical Center, NY (M.A.M., C.J.L.).

9. Department of Laboratory Medicine and Pathology, University of Minnesota School of Medicine, Minneapolis (N.P.).

10. Environmental Public Health Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Chapel Hill, NC (C.K.W.-C.).

11. GeneSTAR Research Program, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD (L.R.Y., D.V., D.M.B., L.C.B.).

12. Department of Geriatrics and Gerontology (S.T.), Leiden University Medical Center, the Netherlands.

13. Department of Cardiology (S.T., J.W.J.), Leiden University Medical Center, the Netherlands.

14. Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany (G.E.D., M.E.K., W.M.).

15. Institute for Translational Genomics and Population Sciences, Department of Pediatrics and Medicine, LABioMed at Harbor–UCLA Medical Center, Torrance, CA (X.G., J.I.R.).

16. Department of Biostatistics (T.M.B., B.M.), University of Washington, Seattle.

17. Institut national de la santé et de la recherche médicale (INSERM), UMR_S 1166, Team Genomics and Pathophysiology of Cardiovascular Diseases, Sorbonne Universités, Université Pierre-et-Marie-Curie, Paris, France (M.G., D.-A.T.).

18. ICAN Institute for Cardiometabolism and Nutrition, Paris, France (M.G., D.-A.T.).

19. Department of Clinical Epidemiology (H.G.d.H., A.v.H.V., F.R.R.), Leiden University Medical Center, the Netherlands.

20. Department of Human Genetics (A.B.O., J.Z.L., D.G.), University of Michigan, Ann Arbor.

21. Faculty of Medicine, University of Split, Croatia (O.P., I.K.).

22. School of Public Health, Department of Biostatistics (A.V.S.), University of Michigan, Ann Arbor.

23. Department of Epidemiology, (A.P.R., B.M.P., N.L.S.), University of Washington, Seattle.

24. Fred Hutchinson Cancer Research Center, Seattle, WA (A.P.R.).

25. Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis (W.T.).

26. Medical Research Council Integrative Epidemiology Unit and Bristol Medical School (N.M.D.), University of Bristol, UK.

27. Academic Section of Geriatrics, Faculty of Medicine (J.D.S.), University of Glasgow, UK.

28. Royal North Shore Hospital, University of Sydney, Australia (G.H.T.).

29. Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX (E.B.).

30. Department of Hematology (M.P.M.d.M.), Erasmus University Medical Center, Rotterdam, the Netherlands.

31. Institute of Nutrition, Friedrich-Schiller-University Jena, Mannheim, Germany (M.E.K.).

32. Institute of Cardiovascular and Medical Sciences (P.W.), University of Glasgow, UK.

33. Department of Medicine (J.A.B., B.M.P.), University of Washington, Seattle.

34. Laboratory of Haematology, La Timone Hospital, Marseille, France (P.S., P.-E.M.).

35. Institut national de la santé et de la recherche médicale (INSERM), UMR_S 1062, Nutrition Obesity and Risk of Thrombosis, Marseille, France (P.S., P.-E.M.).

36. Department of Pediatrics and Communicable Disease (K.D.C.), University of Michigan, Ann Arbor.

37. Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics (P.K.J., H.C., I.R., J.F.W.), University of Edinburgh, Scotland.

38. Laboratory of Epidemiology and Population Sciences National Institute on Aging, Bethesda, MD (L.J.L., T.B.H.).

39. Department of Internal Medicine (F.R., A.G.U.), Erasmus University Medical Center, Rotterdam, the Netherlands.

40. Department of Epidemiology, Harvard H.T. Chan School of Public Health, Boston, MA (A.H.).

41. Institute of Social and Preventive Medicine, University of Bern, Switzerland (O.H.F.).

42. Larner College of Medicine, University of Vermont, Colchester (M.C.).

43. Department of Health Services (B.M.P.), University of Washington, Seattle.

44. Kaiser Permanente Washington Research Institute, Kaiser Permanente Washington, Seattle (B.M.P., N.L.S.).

45. Cardiovascular Health Research Unit (B.M.), University of Washington, Seattle.

46. McMaster University, Population Health Research Institute, Population Health Research Institute, Biochemistry and Biomedical Sciences, Hamilton, Canada (M.R.C.).

47. Stroke Pharmacogenomics and genetics, Department of Neurology, Institut d’Investigació Biomedica Sant Pau, IIB-Sant Pau, Barcelona, Spain (I.F.-C.).

48. Massachusetts General Hospital, Broad Institute, Harvard Medical School, Boston (J.R.).

49. Department of Clinical Sciences Lund, Neurology, Lund University, Sweden (A.L.).

50. Department of Neurology and Rehabilitation Medicine, Neurology, Skåne University Hospital, Lund, Sweden (A.L.).

51. Icelandic Heart Association, Kopavogur (V.G.).

52. Faculty of Medicine, University of Iceland, Reykjavik (V.G.).

53. Brown Foundation Institute of Molecular Medicine (M.F.), University of Texas Health Science Center at Houston.

54. Einthoven Laboratory of Experimental Vascular Medicine (F.R.R., J.W.J.), Leiden University Medical Center, the Netherlands.

55. Unit of Hemostasis and Thrombosis, Hospital de la Sant Creu i Sant Pau, Barcelona, Spain (J.C.S.).

56. Department of Pathology and Laboratory Medicine, University of Vermont College of Medicine, Colchester (N.S.J.).

57. SYNLAB Academy, SYNLAB Holding Deutschland GmbH, Mannheim, Germany (W.M.).

58. Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University Graz, Mannheim, Germany (W.M.).

59. Interuniversity Cardiology Institute of the Netherlands, Utrecht (J.W.J.).

60. Department of Epidemiology and Biostatistics, Imperial College London, UK (A.D.).

61. Cardiology Section Administration, Boston VA Healthcare System, West Roxbury, MA (C.J.O.).

62. Population Health Research Institute, St George’s, University of London, UK (D.P.S.).

63. Seattle Epidemiologic Research and Information Center, Department of Veterans Affairs Office of Research and Development, WA (N.L.S.).

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine

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