1. From the Department of Experimental Medicine, Section of Pharmacology, Second Naples Medical School (A.DA., E.P., D.C., L.M., A.F., L.B., F.R.), Naples, Italy, and Departments of Anesthesia and Medicine and Cardiovascular Division, Brigham and Women’s Hospital, Harvard Medical School (J.F.-M., H.Z., T.H., M.R., K.U., J.K., A.L., P.A.), Boston, Mass.